PepRNA-DB: Peptide-mediated nucleic-acid delivery database

PepRNA-DB is a curated, literature-derived resource for peptide-mediated delivery of RNA and nucleic-acid cargoes, including siRNA, mRNA, antisense oligonucleotides (ASOs), splice-correcting oligonucleotides (SCOs), miRNA, and plasmid DNA.

The database links source publications to peptide sequence and chemistry, nucleic-acid sequences and cargo information, formulation context, biological model, uptake evidence, in vitro functional activity, endosomal escape evidence, and in vivo delivery outcome.

Peptide illustration RNA illustration Peptide-RNA complex illustration

Peptide

RNA

Peptide-RNA complex

Current statistics

509

Literature papers

2582

Curated experiments

466

In vivo experiments

1069

Distinct peptide backbone sequences

336

Distinct nucleic-acid strand pairs

967

Distinct peptide-cargo sequence combinations

1502

Unique peptide names

11

Nucleic-acid cargo classes

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Use the Browse experiments page to search by experiment ID, paper title, DOI, PMID, peptide name, peptide sequence, nucleic-acid cargo type (siRNA, ASO, SCO, mRNA, pDNA, miRNA, and more), or target gene.