Sequence: HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPSC
| Experiment Id | EXP002468 |
|---|---|
| Paper | Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pan |
| Peptide | Exenatide-C / MALAT1 ASO 27 |
| Delivery Success Class | no |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | covalent peptide-ASO conjugate |
| Formulation Format | GLP1R agonist peptide-ASO conjugate |
| Formulation Components | GLP1R agonist peptide ligand covalently conjugated to cEt BNA/DNA gapmer ASO via indicated linker |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | C57BL/6 mice; isolated pancreatic islets analyzed |
| Administration Route | subcutaneous; once weekly for 3 weeks at 0.006 μmol/kg |
| Output Type | MALAT1 mRNA knockdown in pancreatic islets |
| Output Value | No meaningful in vivo Malat-1 knockdown despite in vitro GLP1R activity |
| Output Units | |
| Output Notes | Tested in vivo but did not show functional target knockdown; negative delivery label. |
| Toxicity Notes | |
| Curation Notes |