Sequence: SHGRITFAYFAN
| Experiment Id | EXP002494 |
|---|---|
| Paper | Delivery System Targeting Hemagglutinin of Influenza Virus A to Facilitate Antisense-Based Anti-H1N1 |
| Peptide | HA-binding peptide HABP / H17 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | medium |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | Not clearly specified in main text |
| Mixing Ratio | |
| Formulation Format | Covalent peptide-ODN conjugate |
| Formulation Components | HABP peptide + PROP5 ODN via EMCS linker |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Mouse influenza A infection model referenced in supplemental data |
| Administration Route | Intranasal assumed from study design |
| Output Type | In vivo antiviral functional effect |
| Output Value | Main text states PROP5-HABP showed significant inhibitory effect on IAV replication in vivo; detailed data are in supplemental figures not included here |
| Output Units | |
| Output Notes | Conservatively marked medium confidence because the main article explicitly reports in vivo activity for PROP5-HABP but the detailed supplemental figures were not supplied in this upload. |
| Toxicity Notes | No specific toxicity issue reported for PROP5-HABP in the main text. |
| Curation Notes |