Optimization of cell-penetrating peptides for siRNA delivery (2017)
Sequence: GLWRALWRLLRSLWRLLWK
| Experiment Id | EXP000106 |
|---|---|
| Paper | Optimization of cell-penetrating peptides for siRNA delivery |
| Peptide | CADY-K |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | CPP/siRNA non-covalent complexes |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | Neuro-2a luciferase reporter cells |
| Animal Model | |
| Administration Route | |
| Output Type | luciferase knockdown |
| Output Value | ~70–85% knockdown (best for d-CADY-K) |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |