Sequence: KRRRRRRRR
| Experiment Id | EXP000575 |
|---|---|
| Paper | Conjugates of HA2 with octaarginine-grafted HPMA copolymer offer effective siRNA delivery and gene s |
| Peptide | P-(R8)5.4-FITC |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | 500 nM |
| Mixing Ratio | N/P=12 |
| Formulation Format | polyion complex (PIC) / polyplex |
| Formulation Components | HPMA copolymer + grafted K-R8 (5.4 mol%) + FITC; complexed with RAC1 siRNA |
| Size Nm | 274.10 |
| Zeta Mv | -5.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | SK-OV-3 (uptake imaging); A549 (used in study) |
| Animal Model | |
| Administration Route | |
| Output Type | uptake / complexation |
| Output Value | |
| Output Units | |
| Output Notes | PIC formed but negative zeta; Cy5-siRNA not detected inside cells in confocal imaging (no effective siRNA uptake). |
| Toxicity Notes | Not highlighted as toxic; main toxicity analysis focused on P-(R8)9.5 and HA2-bearing systems. |
| Curation Notes |