Sequence: RRRRRRRRR
| Experiment Id | EXP002188 |
|---|---|
| Paper | Hyaluronic acid-modified cholesterol-conjugated cell-penetrating peptides for nose-to-brain siRNA de |
| Peptide | R9-C |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | HA-coated CPP nanoparticle |
| Formulation Components | HA + cholesterol-R9-C + siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | GL261; U87 |
| Animal Model | |
| Administration Route | cell culture |
| Output Type | gene knockdown |
| Output Value | Significant VEGF/PLK1 silencing |
| Output Units | |
| Output Notes | HA enhances uptake via CD44; CPP mediates internalization |
| Toxicity Notes | Low cytotoxicity |
| Curation Notes |