Sequence: CH3(CH2)16-CONH-Cys-(His)2-(Arg)4-(His)2-Cys-COOH
| Experiment Id | EXP000017 |
|---|---|
| Paper | Disulfide crosslinked stearoyl carrier peptides containing arginine and histidine enhance siRNA upta |
| Peptide | STR-CH2R4H2C |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | disulfide-crosslinked peptide/siRNA complex |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | ICR mice with S-180 sarcoma xenograft |
| Administration Route | Intratumoral injection (day 0, 5, 10) |
| Output Type | tumor growth suppression |
| Output Value | Significant tumor growth inhibition vs naked siRNA |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |