T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice (2008)
Sequence: (D-Arg)9
| Experiment Id | EXP000018 |
|---|---|
| Paper | T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice |
| Peptide | 9R (oligo-9-arginine) |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | scFvCD7 antibody–9R peptide conjugate / siRNA complex |
| Formulation Components | scFvCD7 + oligo-9-arginine + siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | Primary human CD3+ T cells, PBMCs |
| Animal Model | |
| Administration Route | |
| Output Type | gene knockdown (flow cytometry, qPCR) |
| Output Value | CD4 and CCR5 expression reduced; HIV p24 reduced ex vivo |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |