T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice (2008)
Sequence: (D-Arg)9
| Experiment Id | EXP000019 |
|---|---|
| Paper | T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice |
| Peptide | 9R (oligo-9-arginine) |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | scFvCD7 antibody–9R peptide conjugate / siRNA complex |
| Formulation Components | scFvCD7 + oligo-9-arginine + siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Humanized NOD/SCID IL2Rγ−/− mice (Hu-PBL, Hu-HSC) |
| Administration Route | IV injection |
| Output Type | HIV suppression, CD4 T cell preservation |
| Output Value | Suppressed viremia; preserved CD4 T cells; reduced p24 |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |