Sequence: RRRRRRRRR
| Experiment Id | EXP000020 |
|---|---|
| Paper | Matrix metalloproteinase-2 responsive multifunctional peptide-based siRNA delivery system for tumor |
| Peptide | polyarginine R9 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | MMP-2–responsive PEG–peptide micelleplex |
| Formulation Components | PEG–MMP2-cleavable linker–R9–PCL + PLK1 siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | MDA-MB-231, HT-1080 |
| Animal Model | |
| Administration Route | |
| Output Type | gene silencing (PLK1 knockdown) |
| Output Value | ~70–80% PLK1 mRNA reduction |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |