Sequence: RRRRRRRRR
| Experiment Id | EXP000021 |
|---|---|
| Paper | Matrix metalloproteinase-2 responsive multifunctional peptide-based siRNA delivery system for tumor |
| Peptide | polyarginine R9 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | MMP-2–responsive PEG–peptide micelleplex |
| Formulation Components | PEG–MMP2-cleavable linker–R9–PCL + PLK1 siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | MDA-MB-231 breast cancer xenograft (mouse) |
| Administration Route | Intravenous injection |
| Output Type | tumor growth inhibition |
| Output Value | Significant tumor growth suppression with PLK1 siRNA micelles |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |