Octaarginine-modified multifunctional envelope-type nano device for siRNA (2007)
Sequence: RRRRRRRR
| Experiment Id | EXP000025 |
|---|---|
| Paper | Octaarginine-modified multifunctional envelope-type nano device for siRNA |
| Peptide | Octaarginine (R8) |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | R8-modified multifunctional envelope-type nano device (R8-MEND) |
| Formulation Components | siRNA condensed with STR-R8 core + DOPE/CHEMS lipid envelope + surface R8 |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HeLa cells stably expressing luciferase |
| Animal Model | |
| Administration Route | |
| Output Type | luciferase gene silencing |
| Output Value | >80% knockdown at 24 h (15 pmol siRNA) |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |