PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo (2017)
Sequence: kwllrwlsrllrwlarwlg
| Experiment Id | EXP000044 |
|---|---|
| Paper | PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo |
| Peptide | RICK |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | CPP/siRNA nanoparticles |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | U87 glioblastoma (FLuc/NLuc reporter) |
| Animal Model | |
| Administration Route | |
| Output Type | gene knockdown (luciferase, CDK4) |
| Output Value | >80% knockdown at 20 nM siRNA (RICK, ≤20% PEG) |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |