PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo (2017)
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| Experiment Id | EXP000046 |
|---|---|
| Paper | PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo |
| Peptide | RICK |
| Delivery Success Class | no |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | CPP/siRNA nanoparticles |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Zebrafish embryos; C57BL/6 mice |
| Administration Route | Intracardiac injection (mouse); one-cell injection (zebrafish) |
| Output Type | biodistribution and circulation time |
| Output Value | Reduced liver/kidney accumulation; prolonged circulation |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |