Co-delivery of autophagy inhibitor ATG7 siRNA and docetaxel for breast cancer treatment (2017)
Sequence: KVRVRVRVpPTRVRERVK-NH2
| Experiment Id | EXP000047 |
|---|---|
| Paper | Co-delivery of autophagy inhibitor ATG7 siRNA and docetaxel for breast cancer treatment |
| Peptide | CL |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | crosslinked peptide micelles (LA-CLss) |
| Formulation Components | lipoic acid–CL peptide micelles + siATG7 ± docetaxel |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | MCF-7, MDA-MB-231, MDA-MB-468, BT474, SKBR-3 |
| Animal Model | |
| Administration Route | |
| Output Type | ATG7 knockdown, apoptosis, autophagy inhibition |
| Output Value | |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |