Co-delivery of autophagy inhibitor ATG7 siRNA and docetaxel for breast cancer treatment (2017)
Sequence: KVRVRVRVpPTRVRERVK-NH2
| Experiment Id | EXP000048 |
|---|---|
| Paper | Co-delivery of autophagy inhibitor ATG7 siRNA and docetaxel for breast cancer treatment |
| Peptide | CL |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | crosslinked peptide micelles (LA-CLss) |
| Formulation Components | lipoic acid–CL peptide micelles + siATG7 ± docetaxel |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | MCF-7 breast cancer xenograft (BALB/c nude mouse) |
| Administration Route | tail vein injection |
| Output Type | tumor growth inhibition, survival |
| Output Value | |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |