Sequence: CKRRMKWKK
| Experiment Id | EXP000057 |
|---|---|
| Paper | Efficient siRNA delivery using novel cell-penetrating peptide–siRNA conjugate-loaded nanobubbles and |
| Peptide | CKRRMKWKK |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | CPP–siRNA conjugate encapsulated in ultrasound-responsive nanobubbles |
| Formulation Components | CPP–siRNA + PEGylated DSPC/DPPC lipids + perfluorobutane |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | HT-1080 fibrosarcoma xenograft (BALB/c nude mouse) |
| Administration Route | intravenous injection + local ultrasound |
| Output Type | tumor growth inhibition; c-myc silencing |
| Output Value | |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |