Sequence: (YARVRRRGPRR)2–dsRBD
| Experiment Id | EXP000062 |
|---|---|
| Paper | Highly efficient delivery of siRNA to a heart transplant model by a novel cell penetrating peptide–d |
| Peptide | Hph1–Hph1–dsRBD |
| Delivery Success Class | no |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | CPP–dsRBD/siRNA non-covalent complex (± CaCl2 condensation) |
| Formulation Components | Hph1–Hph1–dsRBD fusion protein + siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Mouse heart transplantation model (C57BL/6J) |
| Administration Route | Ex vivo graft perfusion with CPP–siRNA complex |
| Output Type | siRNA distribution in heart tissue |
| Output Value | Widespread siRNA distribution throughout grafted heart |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |