Fatty acid modified octa-arginine for delivery of siRNA (2015)
Sequence: StA–RRRRRRRR
| Experiment Id | EXP000066 |
|---|---|
| Paper | Fatty acid modified octa-arginine for delivery of siRNA |
| Peptide | StA-R8 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | fatty-acid–modified CPP/siRNA electrostatic complexes |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HepG2; A549; LO2 |
| Animal Model | |
| Administration Route | |
| Output Type | survivin mRNA/protein knockdown |
| Output Value | ~50% survivin protein reduction |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |