Sequence: RKKRRQRRR-C
| Experiment Id | EXP000077 |
|---|---|
| Paper | Novel cell-penetrating peptide-loaded nanobubbles synergized with ultrasound irradiation enhance EGF |
| Peptide | RKKRRQRRR-Cys (TAT-Cys) |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | CPP-loaded nanobubbles + UTMD |
| Formulation Components | DSPE-PEG2000-MAL nanobubbles + CPP + siEGFR |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | MDA-MB-231 TNBC xenograft (BALB/c nude mouse) |
| Administration Route | intravenous injection + ultrasound |
| Output Type | tumor growth inhibition; EGFR mRNA/protein suppression |
| Output Value | |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |