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EXP000078

Paper

Formulation and in vitro evaluation of a siRNA delivery nanosystem decorated with gH625 peptide for triple negative breast cancer theranosis (2018)

Peptide

gH625

Sequence: H-Gly-Ala-Leu-Ser-Ala-Leu-Gly-Ala-Ala-Leu-Ala-Leu-Gly-Ala-Ala-Leu-Ala-Leu-Gly-Ala-Ala-Leu-Ala-Leu-Gly-Ala-Ala-Leu-Ala-Leu-OH

RNA

siRNA

All experiment fields

Experiment Id EXP000078
Paper Formulation and in vitro evaluation of a siRNA delivery nanosystem decorated with gH625 peptide for
Peptide gH625
Delivery Success Class no
In Vivo Flag no
Uptake Confirmed yes
Label Confidence
In Vitro Functional Effect yes
Endosomal Escape Evidence yes
Peptide Concentration
Rna Concentration
Mixing Ratio
Formulation Format SPION-based nanovector (CS-MSN)
Formulation Components PEGylated SPION + gH625 + chitosan + poly-L-arginine
Size Nm
Zeta Mv
Model Scope in_vitro
Model Type in vitro
Cell Lines Or Primary Cells MDA-MB-231; MDA-MB-231/GFP
Animal Model
Administration Route
Output Type GFP knockdown
Output Value 73 ± 3% knockdown
Output Units
Output Notes
Toxicity Notes
Curation Notes