Peptide-mediated delivery of therapeutic mRNA in ovarian cancer (2019)
Sequence: Stearyl-AGYLLGSRRDLARALRRHLALRL
| Experiment Id | EXP000081 |
|---|---|
| Paper | Peptide-mediated delivery of therapeutic mRNA in ovarian cancer |
| Peptide | PepFect14 (PF14) |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | CPP/mRNA nanoparticles |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | SKOV-3-GFP/Luc intraperitoneal xenograft (nude mouse) |
| Administration Route | intraperitoneal injection |
| Output Type | reporter protein expression in tumor microenvironment |
| Output Value | |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |