Sequence: Cys-His-His-Arg-Arg-Arg-His-His-Cys
| Experiment Id | EXP000083 |
|---|---|
| Paper | Systemic delivery of siRNA to the colon using peptide modified PEG-PCL polymer micelles for the trea |
| Peptide | CH2R4H2C |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | PEG-PCL polymer micelles with CPP |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | DSS-induced ulcerative colitis mouse model (C57BL/6) |
| Administration Route | intravenous injection |
| Output Type | Reduced clinical score, restored colon length, reduced TNF-α |
| Output Value | |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |