A novel peptide for efficient siRNA delivery in vitro and therapeutics in vivo (2015)
Sequence: Ac-PKPKRKV-NH2
| Experiment Id | EXP000086 |
|---|---|
| Paper | A novel peptide for efficient siRNA delivery in vitro and therapeutics in vivo |
| Peptide | H0K |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | CPP/siRNA electrostatic complexes |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | A549 lung cancer cells |
| Animal Model | |
| Administration Route | |
| Output Type | Bcl-2 mRNA knockdown |
| Output Value | Highest for STR-HK (~78%); others lower |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |