Tumor-targeted delivery of siRNA by RGD10-10R peptide (2015)
Sequence: DGARYCRGDCFDGRRRRRRRRRR
| Experiment Id | EXP000101 |
|---|---|
| Paper | Tumor-targeted delivery of siRNA by RGD10-10R peptide |
| Peptide | RGD10-10R |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | CPP/siRNA electrostatic complexes |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | MDA-MB-231 breast cancer cells |
| Animal Model | |
| Administration Route | |
| Output Type | LMNA knockdown |
| Output Value | ~70% knockdown |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |