Tumor-targeted delivery of siRNA by RGD10-10R peptide (2015)
Sequence: DGARYCRGDCFDGRRRRRRRRRR
| Experiment Id | EXP000102 |
|---|---|
| Paper | Tumor-targeted delivery of siRNA by RGD10-10R peptide |
| Peptide | RGD10-10R |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | CPP/siRNA electrostatic complexes |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | MDA-MB-231 breast cancer cells |
| Animal Model | MDA-MB-231 breast cancer xenograft (nude mouse) |
| Administration Route | intravenous injection |
| Output Type | tumor-targeted gene silencing |
| Output Value | significant LMNA suppression in tumor |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |