Sequence: RRRRRRRRR (r9)
| Experiment Id | EXP000114 |
|---|---|
| Paper | Albumin Biomimetic Nanocorona Improves Tumor Targeting and Penetration for Synergistic Therapy of Me |
| Peptide | r9-S-S-DOPE |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | 1–2 µg siRNA per well (CPP excess) |
| Rna Concentration | 1–2 µg siRNA per well |
| Mixing Ratio | 9:1 (w/w) CPP:siRNA |
| Formulation Format | CPP nanoassembly (r9-S-S-DOPE / DOPE / IR-780) ± HSA |
| Formulation Components | ~130 nm (with HSA) |
| Size Nm | |
| Zeta Mv | 3.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | 4T1 metastatic breast cancer cells |
| Animal Model | |
| Administration Route | |
| Output Type | gene knockdown / antimigration |
| Output Value | |
| Output Units | |
| Output Notes | Twist knockdown, cytosolic localization, migration suppression ± laser |
| Toxicity Notes | |
| Curation Notes |