Sequence: RRRRRRRRR (r9)
| Experiment Id | EXP000115 |
|---|---|
| Paper | Albumin Biomimetic Nanocorona Improves Tumor Targeting and Penetration for Synergistic Therapy of Me |
| Peptide | r9-S-S-DOPE |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | 0.5 mg siRNA/kg |
| Rna Concentration | 1.0 mg siRNA/kg |
| Mixing Ratio | 9:1 (w/w) CPP:siRNA; HSA 4:1 (w/w) |
| Formulation Format | CPP nanoassembly (r9-S-S-DOPE / DOPE / IR-780) ± HSA |
| Formulation Components | ~130 nm |
| Size Nm | |
| Zeta Mv | 3.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Orthotopic 4T1 breast cancer mouse model |
| Administration Route | IV (tail vein) |
| Output Type | tumor growth inhibition / metastasis prevention |
| Output Value | 83.6% tumor inhibition; 92.2% lung metastasis inhibition |
| Output Units | |
| Output Notes | |
| Toxicity Notes | No significant body weight loss or systemic toxicity |
| Curation Notes |