Sequence: poly(sulfadimethoxine) peptide-polymer (no PHis)
| Experiment Id | EXP000146 |
|---|---|
| Paper | Stimuli-responsive release and efficient siRNA delivery in non-small cell lung cancer by a poly(L-hi |
| Peptide | PD (PEG-PSD) coated PLL |
| Delivery Success Class | no |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | N/P = 4 |
| Rna Concentration | 1 mg siRNA/kg |
| Mixing Ratio | PLL:PD:siRNA optimized |
| Formulation Format | PLL/siRNA nanoparticle with polymer coating |
| Formulation Components | ~101 nm |
| Size Nm | |
| Zeta Mv | 5.70 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | A549 xenograft nude mouse |
| Administration Route | IV (tail vein) |
| Output Type | tumor growth inhibition |
| Output Value | Moderate tumor inhibition (<50%) |
| Output Units | |
| Output Notes | |
| Toxicity Notes | No significant systemic toxicity |
| Curation Notes |