Sequence: poly(L-histidine) peptide-polymer (PHis)
| Experiment Id | EXP000147 |
|---|---|
| Paper | Stimuli-responsive release and efficient siRNA delivery in non-small cell lung cancer by a poly(L-hi |
| Peptide | PHD (PEG-PHis-PSD) coated PLL |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | N/P = 4 (PLL:siRNA) |
| Rna Concentration | 100 nM siRNA |
| Mixing Ratio | PLL:PHD:siRNA optimized |
| Formulation Format | PLL/siRNA nanoparticle with polymer coating |
| Formulation Components | ~102 nm |
| Size Nm | |
| Zeta Mv | 5.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | A549, MCF-7 |
| Animal Model | |
| Administration Route | |
| Output Type | gene knockdown / apoptosis |
| Output Value | |
| Output Units | |
| Output Notes | Strong PLK1 knockdown, G2/M arrest, apoptosis |
| Toxicity Notes | |
| Curation Notes |