Sequence: poly(L-histidine) peptide-polymer (PHis)
| Experiment Id | EXP000148 |
|---|---|
| Paper | Stimuli-responsive release and efficient siRNA delivery in non-small cell lung cancer by a poly(L-hi |
| Peptide | PHD (PEG-PHis-PSD) coated PLL |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | N/P = 4 |
| Rna Concentration | 1 mg siRNA/kg |
| Mixing Ratio | PLL:PHD:siRNA optimized |
| Formulation Format | PLL/siRNA nanoparticle with polymer coating |
| Formulation Components | ~102 nm |
| Size Nm | |
| Zeta Mv | 5.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | A549 xenograft nude mouse |
| Administration Route | IV (tail vein) |
| Output Type | tumor growth inhibition |
| Output Value | ~67% tumor inhibition; PLK1 downregulation |
| Output Units | |
| Output Notes | |
| Toxicity Notes | No significant weight loss or organ toxicity |
| Curation Notes |