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EXP000154

Paper

A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA (2021)

Peptide

OligoArg (Arg9)

Sequence: RRRRRRRRR

RNA

mRNA

All experiment fields

Experiment Id EXP000154
Paper A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of th
Peptide OligoArg (Arg9)
Delivery Success Class no
In Vivo Flag no
Uptake Confirmed yes
Label Confidence high
In Vitro Functional Effect yes
Endosomal Escape Evidence
Peptide Concentration N/P = 2–4
Rna Concentration 0.5 µg mRNA
Mixing Ratio N/P = 2 or 4
Formulation Format Oligopeptide–mRNA electrostatic polyplex
Formulation Components ~200–1100 nm (N/P dependent)
Size Nm
Zeta Mv
Model Scope in_vitro
Model Type in vitro
Cell Lines Or Primary Cells HuH-7
Animal Model
Administration Route
Output Type protein expression
Output Value
Output Units
Output Notes Short-lived luciferase expression; rapid intracellular mRNA degradation
Toxicity Notes
Curation Notes