Delivery of siRNA Using Lipid Nanoparticles Modified with Cell Penetrating Peptide (2016)
Sequence: RRRRRRRR (octaarginine) with oleoyl chain
| Experiment Id | EXP000157 |
|---|---|
| Paper | Delivery of siRNA Using Lipid Nanoparticles Modified with Cell Penetrating Peptide |
| Peptide | OA-R8 + Tf (sTOLP) |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | OA-R8/Tf-modified LNP (sTOLP) |
| Formulation Components | ~150 nm |
| Size Nm | |
| Zeta Mv | 5.40 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HepG2 |
| Animal Model | |
| Administration Route | |
| Output Type | gene knockdown |
| Output Value | |
| Output Units | |
| Output Notes | Highest uptake and knockdown among formulations |
| Toxicity Notes | |
| Curation Notes |