Delivery of siRNA Using Lipid Nanoparticles Modified with Cell Penetrating Peptide (2016)
Sequence: RRRRRRRR (octaarginine) with oleoyl chain
| Experiment Id | EXP000159 |
|---|---|
| Paper | Delivery of siRNA Using Lipid Nanoparticles Modified with Cell Penetrating Peptide |
| Peptide | OA-R8 + Tf (sTOLP) |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | OA-R8/Tf-modified LNP (sTOLP) |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | HepG2 xenograft nude mouse |
| Administration Route | IV |
| Output Type | tumor growth inhibition |
| Output Value | 61.7% tumor inhibition |
| Output Units | |
| Output Notes | |
| Toxicity Notes | No hepatic, renal, or immune toxicity |
| Curation Notes |