Sequence: R16KRPTMRFRYTWNPMK
| Experiment Id | EXP000182 |
|---|---|
| Paper | Hepatic carcinoma selective nucleic acid nanovector assembled by endogenous molecules based on modul |
| Peptide | P1 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | HA-coated lipopolyplex (HLP1R) |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | SMMC-7721 liver orthotopic tumor (BALB/c nude mice) |
| Administration Route | IV (tail vein) |
| Output Type | in vivo gene silencing |
| Output Value | ~77% survivin mRNA knockdown in tumor |
| Output Units | |
| Output Notes | |
| Toxicity Notes | No significant body weight loss or organ toxicity |
| Curation Notes |