Sequence: Fluorinated poly(L-lysine) peptide dendrimer
| Experiment Id | EXP000186 |
|---|---|
| Paper | Highly Efficient and Safe Delivery of VEGF siRNA by Bioreducible Fluorinated Peptide Dendrimers for |
| Peptide | BFPD-11 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | BFPD-11/siRNA polyplex |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | HeLa xenograft nude mice |
| Administration Route | Intratumoral |
| Output Type | Tumor growth inhibition |
| Output Value | Strong inhibition for BFPD-11/12; weak for BFPD-21 |
| Output Units | |
| Output Notes | |
| Toxicity Notes | No significant toxicity |
| Curation Notes |