NF-κB Inhibition Suppresses Experimental Melanoma Lung Metastasis (2020)
Sequence: p5RHH amphipathic peptide (histidine-rich; exact sequence proprietary/previously published)
| Experiment Id | EXP000201 |
|---|---|
| Paper | NF-κB Inhibition Suppresses Experimental Melanoma Lung Metastasis |
| Peptide | p5RHH |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | 0.5 mg siRNA/kg (3 injections) |
| Mixing Ratio | 100:1 peptide:siRNA |
| Formulation Format | p5RHH–p65 siRNA nanoparticles |
| Formulation Components | ~55 nm |
| Size Nm | |
| Zeta Mv | 33.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | B16-F10 melanoma lung metastasis (C57BL/6 mice) |
| Administration Route | Intravenous (tail vein) |
| Output Type | tumor growth inhibition |
| Output Value | 76% reduction in lung metastasis burden |
| Output Units | |
| Output Notes | |
| Toxicity Notes | No reported systemic toxicity or immune activation |
| Curation Notes |