Sequence: Cys-His-His-Arg-Arg-Arg-Arg-His-His-Cys
| Experiment Id | EXP000203 |
|---|---|
| Paper | Anti-Metastatic Effects on Melanoma via Intravenous Administration of Anti-NF-κB siRNA Complexed wit |
| Peptide | CH2R4H2C |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | N/P 10 |
| Formulation Format | siRelA/MPEG-PCL-CH2R4H2C micelles |
| Formulation Components | ~50 nm |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | B16F10 lung metastasis (C57BL/6 mice) |
| Administration Route | Intravenous |
| Output Type | metastasis inhibition |
| Output Value | Significant reduction in lung metastatic nodules |
| Output Units | |
| Output Notes | |
| Toxicity Notes | No systemic toxicity; 100% survival |
| Curation Notes |