The Potential of Cell-Penetrating Peptides for mRNA Delivery to Cancer Cells (2022)
Sequence: WEARLARALARALARHLARALARALRACEA
| Experiment Id | EXP000209 |
|---|---|
| Paper | The Potential of Cell-Penetrating Peptides for mRNA Delivery to Cancer Cells |
| Peptide | RALA |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | CPP/mRNA electrostatic nanocomplex |
| Formulation Components | <200 nm |
| Size Nm | |
| Zeta Mv | 5.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | CT26.CL25; HEK293T |
| Animal Model | |
| Administration Route | |
| Output Type | mRNA expression |
| Output Value | |
| Output Units | |
| Output Notes | Efficient expression only for p5RHH (highest), STR-Arg8 and RALA; others poor |
| Toxicity Notes | |
| Curation Notes |