Sequence: Stearoyl-AGYLLGDabLKALAALAKAIL-NH2
| Experiment Id | EXP000220 |
|---|---|
| Paper | The Development of Cell-Penetrating Peptides for Efficient and Selective In Vivo Expression of mRNA |
| Peptide | NF424 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | CPP/mRNA nanoparticles (CR 2:1) |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | BALB/c mice |
| Administration Route | Intravenous (tail vein) |
| Output Type | in vivo mRNA expression |
| Output Value | Spleen-selective luciferase expression |
| Output Units | |
| Output Notes | >95% of reporter signal in spleen; dendritic-cell dominant expression |
| Toxicity Notes | |
| Curation Notes |