Lipid- and Histidine-Modified Cell-Penetrating Peptides for siRNA Delivery (2020)
Sequence: HHHHHALWKTLLKKVLKAPKKKRKVC
| Experiment Id | EXP000224 |
|---|---|
| Paper | Lipid- and Histidine-Modified Cell-Penetrating Peptides for siRNA Delivery |
| Peptide | H5-S413-PV |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | Non-covalent CPP/siRNA nanocomplex |
| Formulation Components | ~170–400 nm (variant-dependent) |
| Size Nm | |
| Zeta Mv | 11.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | U87 glioblastoma; HeLa |
| Animal Model | |
| Administration Route | |
| Output Type | gene silencing / uptake |
| Output Value | |
| Output Units | |
| Output Notes | Best performance observed for C12-H5-S413-PV; others moderate to weak |
| Toxicity Notes | |
| Curation Notes |