Sequence: GGGRRRRRRRRR (3G9R core); Tat: GRKKRRQRRRPPQ
| Experiment Id | EXP000228 |
|---|---|
| Paper | Self-Assembling Lipid–Peptide Hybrid Nanoparticles of Phospholipid–Nonaarginine Conjugates for Enhan |
| Peptide | Nonaarginine (9R) + Tat |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | 7.52 µM siRNA per mouse |
| Rna Concentration | 7.52 µM per mouse |
| Mixing Ratio | N/P = 10 |
| Formulation Format | lipid–peptide hybrid nanoparticle (T-hNP) |
| Formulation Components | PL9R + siRNA + lipid envelope + Tat |
| Size Nm | 170.00 |
| Zeta Mv | 7.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | HeLa-Luc xenograft mouse model |
| Administration Route | intravenous (tail vein) |
| Output Type | tumor gene silencing |
| Output Value | ~55% reduction in tumor bioluminescence |
| Output Units | |
| Output Notes | Sustained silencing up to 48 h; superior to non-Tat hNP |
| Toxicity Notes | No significant toxicity or hemolysis |
| Curation Notes |