Delivery of siRNA complexed with palmitoylated α-peptide–β-peptoid cell-penetrating peptidomimetics (2015)
Sequence: α/β-peptoid chimera; X=Ac; n=3 (Fig.1)
| Experiment Id | EXP000323 |
|---|---|
| Paper | Delivery of siRNA complexed with palmitoylated α-peptide–β-peptoid cell-penetrating peptidomimetics |
| Peptide | Ac-α/β-peptoid-4 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | variable |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | nanocomplex |
| Formulation Components | Ac-α/β-peptoid-4 + siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HeLa, U2OS |
| Animal Model | |
| Administration Route | |
| Output Type | uptake only |
| Output Value | |
| Output Units | |
| Output Notes | Cellular uptake observed but poor knockdown |
| Toxicity Notes | Low toxicity |
| Curation Notes |