Sequence: c[CONH2-EWEAKLAKALAKALAKHLAK-NH2]-Fmoc
| Experiment Id | EXP000328 |
|---|---|
| Paper | Cell Penetrating Peptides Functionalized siRNA Nanoparticles Knockdown HER Receptors in Breast Cance |
| Peptide | cKALA |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | 200–600 nM |
| Mixing Ratio | |
| Formulation Format | nanoparticle |
| Formulation Components | methylated protamine + CPP + siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | BT474, SKBR3 |
| Animal Model | |
| Administration Route | |
| Output Type | gene knockdown |
| Output Value | ~50% HER2 mRNA reduction |
| Output Units | |
| Output Notes | Comparable knockdown to cTAT |
| Toxicity Notes | >90% cell viability |
| Curation Notes |