Sequence: RRRRRRRRR
| Experiment Id | EXP000349 |
|---|---|
| Paper | Efficient Liposomal Nanocarrier-mediated Oligodeoxynucleotide Delivery Involving Dual Use of a Cell- |
| Peptide | 9R |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | Varied to achieve N/P ratios up to 1:6 |
| Rna Concentration | 0.5 μM ODN (cell studies) |
| Mixing Ratio | 9R/ODN charge ratio 6:1 |
| Formulation Format | CPP-modified liposome |
| Formulation Components | POPC/POPG/Chol/PEG-DSPE liposome + 9R/ODN polyplex |
| Size Nm | 106.00 |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | U87MG human glioblastoma cells |
| Animal Model | |
| Administration Route | |
| Output Type | ODN uptake; NF-κB inhibition; chemosensitization; apoptosis |
| Output Value | Enhanced paclitaxel sensitivity; increased apoptosis; reduced viability |
| Output Units | |
| Output Notes | Cytosolic delivery of ODN; prolonged intracellular retention; functional NF-κB inhibition demonstrated |
| Toxicity Notes | Moderate cytotoxicity (~20% viability reduction) attributed to 9R/ODN core |
| Curation Notes |