A self-accelerating endosomal escape siRNA delivery nanosystem for suppressing hyperplasia (2019)
Sequence: WGRRRRRRRRGC
| Experiment Id | EXP000374 |
|---|---|
| Paper | A self-accelerating endosomal escape siRNA delivery nanosystem for suppressing hyperplasia |
| Peptide | W-G-R8-G-C |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | 8 µg per injection |
| Mixing Ratio | |
| Formulation Format | ternary nanoparticle |
| Formulation Components | POSS-(C-G-R8-G-W)16 / PLL-g-Aco / ERK2-siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Bleomycin-induced dermal fibrosis mouse model |
| Administration Route | intradermal injection |
| Output Type | phenotypic rescue |
| Output Value | Dermal thickness reduced ~37.5%, fibrosis suppressed |
| Output Units | |
| Output Notes | Direct in vivo siRNA delivery and therapeutic effect |
| Toxicity Notes | No systemic toxicity reported |
| Curation Notes |