PSA-responsive and PSMA-mediated multifunctional liposomes for targeted therapy of prostate cancer (2013)
Sequence: (DGG)4-HSSKYQ-G-(D-Arg)8-G-C
| Experiment Id | EXP000375 |
|---|---|
| Paper | PSA-responsive and PSMA-mediated multifunctional liposomes for targeted therapy of prostate cancer |
| Peptide | ACPP |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | 75–100 nM |
| Mixing Ratio | |
| Formulation Format | liposome |
| Formulation Components | DSPE-PEG-peptide / folate / DC-Chol liposome |
| Size Nm | 180.00 |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | 22Rv1, PC-3 |
| Animal Model | |
| Administration Route | |
| Output Type | gene knockdown & apoptosis |
| Output Value | PLK-1 mRNA/protein ↓, apoptosis ↑ |
| Output Units | |
| Output Notes | Clear PSA-triggered uptake and silencing |
| Toxicity Notes | Low cytotoxicity |
| Curation Notes |