PSA-responsive and PSMA-mediated multifunctional liposomes for targeted therapy of prostate cancer (2013)
Sequence: (DGG)4-HSSKYQ-G-(D-Arg)8-G-C
| Experiment Id | EXP000377 |
|---|---|
| Paper | PSA-responsive and PSMA-mediated multifunctional liposomes for targeted therapy of prostate cancer |
| Peptide | ACPP |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | 1.5 mg/kg |
| Mixing Ratio | |
| Formulation Format | liposome |
| Formulation Components | DSPE-PEG-peptide / folate / DC-Chol liposome |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | 22Rv1 xenograft mouse model |
| Administration Route | intravenous |
| Output Type | tumor growth inhibition |
| Output Value | Tumor growth suppressed, PLK-1 knockdown |
| Output Units | |
| Output Notes | Systemic siRNA delivery with tumor targeting |
| Toxicity Notes | No significant toxicity reported |
| Curation Notes |