Sequence: Ac-CLRLRLRLRCG-NH2
| Experiment Id | EXP000399 |
|---|---|
| Paper | Impact of Peptide Sequence on Functional siRNA Delivery and Gene Knockdown with Cyclic Amphipathic P |
| Peptide | [LR]4 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | 13–33 µM |
| Rna Concentration | 33–132 nM |
| Mixing Ratio | N/P ≈190 |
| Formulation Format | peptide/siRNA nanoparticle |
| Formulation Components | CAP peptide + siRNA |
| Size Nm | 135.00 |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | A549 lung adenocarcinoma cells |
| Animal Model | |
| Administration Route | |
| Output Type | gene knockdown |
| Output Value | TTF-1 mRNA knockdown (50–85%) |
| Output Units | |
| Output Notes | In vitro structure–function study |
| Toxicity Notes | Low cytotoxicity |
| Curation Notes |