Lipoplex and peptide-based strategies for the delivery of steric-block oligonucleotides (2007)
Sequence: GRKKRRQRRR
| Experiment Id | EXP000409 |
|---|---|
| Paper | Lipoplex and peptide-based strategies for the delivery of steric-block oligonucleotides |
| Peptide | Tat-PNA705 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | 0.5–1 µM |
| Mixing Ratio | |
| Formulation Format | peptide–PNA conjugate |
| Formulation Components | CPP–PNA conjugate |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HeLa pLuc/705 cells |
| Animal Model | |
| Administration Route | |
| Output Type | splice correction (luciferase) |
| Output Value | Luciferase activation via splice correction |
| Output Units | |
| Output Notes | CPP-conjugated PNA delivery |
| Toxicity Notes | Low cytotoxicity |
| Curation Notes |